Identification of tumor suppressor genes

Hi,

I have a question about gene effect score and gene dependency score.

1. Does essentiality only mean that knocking out a gene will cause cancer cells to stop growing or even die? Is there a reverse concept, that knocking out a gene can cause cancer cells to proliferate?
   We know that the more negative the gene effect score, the more likely the gene is to promote tumor growth. So maybe we can assume that the more positive the effect score, the more likely the gene is to suppress tumor growth?
2. gene dependency is the probability that a gene is essential, right? Then can this number only be used to identify genes that promote tumor growth (>0.5), but not genes that inhibit tumor growth?

Thanks

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