Discrepancy between two damaging mutation file from 23Q4

Hi DepMap team,

I noticed a discrepancy between damaging_mutations.csv (downloaded from “Downloads/Custom Downloads” page) and OmicsSomaticMutationsMatrixDamaging.csv (downloaded from “Downloads/All Data” page). For example, damaging_mutations.csv included 17514 genes and OmicsSomaticMutationsMatrixDamaging.csv included 18748 genes.

I wonder if the pipeline that used to generate these two files are the same, if not, where the discrepancy comes from? To analyze damaging mutations across cell lines, which file is recommended to use?

Thanks.

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