Hi,
I have noticed in many of the updates that the OmicsCNGene.csv NaN are primarily for Y-chromosome genes. My assumptions are that these are a result of a lack of Y-chromosome mapped segments in XX individuals or cell-lines that have lost their Y-chromosome. If this assumption is true, would it be appropriate to replace these NaN with a zero in subsequent analysis?
I am a bit hesitant due to the existence of zero valued entries for other genes, so I was wondering if there are reasons NOT to assume these biases of NaN entries for Y-chromosome genes are due to the absence of a Y-chromosome in certain samples? Thank you!
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