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PRISM Repurposing Public 23Q2 two-class comparison shift from 0

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I did a two-class comparison for the PRISM Repurposing Public 23Q2 data for a few lineages of interest and found that the distribution of effect sizes is not centering at 0 (whereas in the Skyros internal data portal it did). Seems like some systematic probably with calculating the effect size?

For Ewing lines:

For rhabdomyosarcoma lines:

For dedifferentiated/well-differentiated liposarcoma lines:

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